Description
GLP-3R
Triple Receptor Agonist Peptide – Research Grade
GLP-3R is an investigational synthetic peptide engineered as a tri-agonist targeting the GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors. The compound is designed to simultaneously modulate incretin and glucagon signaling pathways involved in systemic metabolic regulation.
By integrating receptor activity across multiple endocrine axes, GLP-3R is utilized in preclinical research to evaluate coordinated effects on glucose homeostasis, energy balance, adiposity, and lipid metabolism. Unlike mono-receptor or dual-receptor agonists, this tri-agonist construct enables investigation of synergistic receptor activation and downstream metabolic signaling cascades within a unified pharmacological framework.
Mechanistic Overview (Preclinical Research Context)
GLP-3R exerts activity through concurrent engagement of:
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GLP-1 receptors (GLP-1R): Associated with glucose-dependent insulinotropic signaling and central appetite modulation pathways.
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GIP receptors (GIPR): Implicated in potentiation of insulin secretion and nutrient partitioning mechanisms.
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Glucagon receptors (GCGR): Linked to hepatic glucose output regulation, lipid mobilization, and increased energy expenditure.
The coordinated activation of these receptor systems allows for the evaluation of metabolic adaptation models addressing both caloric intake regulation and thermogenic output.
Investigational Applications
GLP-3R is employed in laboratory and preclinical settings for research involving:
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Regulation of glycemic control mechanisms
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Insulin signaling pathway modulation
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Energy expenditure and substrate oxidation studies
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Adipose tissue metabolism investigations
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Hepatic lipid metabolism models
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Integrated approaches to metabolic syndrome research
This tri-receptor approach provides a platform for assessing multi-pathway endocrine interactions in metabolic disease models.
Product Specifications
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Quantity: 10 mg per vial
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Purity: 99% (HPLC)
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Classification: Triple incretin/glucagon receptor agonist peptide
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Molecular Weight: ~4.9 kDa (salt form dependent)
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Physical Form: Lyophilized powder
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CAS Registry: Pending assignment (research compound designation)
Handling and Storage
Store the lyophilized peptide under controlled conditions in a dry, light-protected environment at recommended storage temperatures.
Following reconstitution with bacteriostatic water, maintain refrigeration and use within established laboratory stability parameters.
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